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Oxidative stress disrupts the integrity of the BBB through mechanisms that result from an excess of reactive oxygen species (ROS) accompanied by a compromised intrinsic antioxidant defense [81]

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In practice, the most meaningful shifts tend to come from supporting the systems that drive long-term resilience used when the right clinical markers indicate a need: NAD support compounds that maintain cellular energy and repair pathways used when testing shows low NAD status, mitochondrial strain or impaired energy metabolism

Feng H, Schorpp K, Jin J, Yozwiak CE, Hoffstrom BG, Decker AM, et al

They support different but complementary systems in the body