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If you have cirrhosis or creatinine clearance below 15 mL/min, alternative weight loss approaches may be safer pending more robust safety data in these populations

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Patients with severe hepatic or renal impairment may require special consideration, though specific dosing guidelines for these populations have not been established

The front and outer thigh offer a generous area of subcutaneous tissue, easy access without contortion, and absorption rates that clinical research confirms are comparable to the abdomen

The rat MCL study showed progressive improvement at 14, 30, 45, and 90 days