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It is not a drug, food, supplement, or cosmetic, is not approved by the FDA, and is not intended to diagnose, treat, cure, or prevent any disease, or for human or veterinary consumption

Most proteins unfold at low or high pHs (below 5 and above 10) because the folded protein has groups buried in non-ionized form that can ionize only after unfolding, particularly the His and Tyr residues that tend to cause unfolding at acid and alkaline pH, respectively

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Cell-Penetrating Peptides in Diagnosis and Treatment of Human Diseases: From Preclinical Research to Clinical Application

Higashi T, Friedman SL, Hoshida Y