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Because semaglutide slows down digestion, food stays in the stomach longer

Parietal cells also show fairly strong expression of the GLP-1R (73), and GLP-1 has been shown to inhibit gastric acid secretion in humans, although the importance of this effect is currently unclear (99)

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Additionally, new or worsening constipation accompanied by unexplained weight loss (beyond expected therapeutic weight reduction), persistent changes in stool caliber, or alternating constipation and diarrhea warrants evaluation to exclude structural or neoplastic causes, particularly in patients age 45 or older or those with family history of colorectal cancer

Since blood sugar fluctuations can cause energy crashes and increased cravings, having a little help can make a difference