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Nahum Mndez-Snchez, Liver Research Unit, Medica Sur Clinic and Foundation, 150 Puente de Piedra, Tlalpan, Mexico City 14050, Mexico Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico

Because three receptor systems are involved, reducing the dose to manage side effects may disproportionately affect one pathway more than others, leading to unpredictable changes in the benefit profile