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GLP-1 receptor activation by native GLP-1 or GLP-1RAs leads to insulin secretion and lowers inappropriately high glucagon secretion in a glucose-dependent manner, thereby improving glycemic control [3]

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1 Introduction Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia (elevated blood glucose), which is caused by a lack of insulin or failure of insulin, resulting in cells being unable to absorb glucose, thus increasing blood glucose levels