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If the vitamin B12 is ingested in its protein bound form, then it must first undergo a proteolytic cleavage in the stomach or duodenum where it will bind to an R-binder and then enter into the duodenum for further cleavage.1,2,8 This proteolytic cleavage is mostly dependent on the functional activity of pepsin

April 23, 2026 effective date: twelve peptides come off the Category 2 do not compound list, after their nominations were withdrawn