Theriogenology 64 , 29 (2018)
(iii) Safety Endpoints: Rare events and data scarcity place the posterior in a gray zone, best presented through probabilistic language that defines the boundaries of risks that can neither be confirmed nor excluded ( Consequently, clinical communication can shift from binary assertions (effective/ineffective, safe/unsafe) to a framework of probabilities + intervals + acceptance thresholds. For instance, the posterior probability of reaching a clinically meaningful weight-loss threshold can be presented alongside the posterior uncertainty of benefits in hard reproductive endpoints, rather than replacing the decision process with a single P -value
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estrogen-like metabolites, capable of reaction with DNA to form DNA-adducts and liberation of ROS, have been implicated as initiators of squamous cell carcinoma during urogenital schistosomiasis caused by infection with Schistosoma haematobium [24]
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