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Hypothyroid symptoms include unexplained fatigue, cold intolerance, constipation, dry skin, or unintended weight gain despite continued semaglutide use

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Several FDA-approval drugs will be discussed, including liraglutide, semaglutide, tirzepatide, orlistat, and combinations like phentermine/topiramate and bupropion/naltrexone, noting their effectiveness in obesity management [34, 35] (Table 1)

It wasnt all bad news, with an extremely strong launch for the Wegovy pill, and a reminder of strong clinical progress in the next-generation pipeline at the tail-end of 2025. In London, Britains second-biggest drugmaker, GSK, said sales growth would slow to between 3% and 5% this year, from 7% growth to 32.7bn last year

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