Leptin is a hormone involved in regulating energy balance and appetite, which could imply that increased food intake may contribute to the observed weight gain in peptide-exposed models, which then may increase leptin levels and subdue appetite
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At the 6-year post-hoc analysis, serious ARs occurred in 42% of patients who received IMFINZI + IMJUDO, and no new serious treatment-related safety events were reported 1-3 Fatal ARs occurred in 8% of patients who received IMFINZI + IMJUDO, including death (1%), hemorrhage intracranial (0.5%), cardiac arrest (0.5%), pneumonitis (0.5%), hepatic failure (0.5%), and immune-mediated hepatitis (0.5%) 1,2 Permanent discontinuation due to ARs occurred in 14% of patients receiving IMFINZI + IMJUDO
Critically, it points to the fact that vagal signalling is not essential to relay ascending orexigenic messages, likely due to the fact that the area postrema can facilitate diffusive access of ghrelin from the bloodstream to the NTS, enabling ascending signalling even without vagal innervation of the NTS
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