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Paraxanthine exhibits lower toxicity than caffeine and is less clastogenic compared to caffeine or theophylline

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The underlying mechanism is believed to be associated with estrogens influence on critical brainstem regions integral to neurocardiovascular regulation (54)

19461948: The MRC and the Birth of Randomization: For two centuries, trials were still a bit biased, doctors often gave the new medicine to patients they thought had the best chance of survival