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Additionally, Methylcobalamin has been used to treat Leber's disease, a rare inherited eye disorder

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For instance, Health Canada has prohibited the sale of supplements containing kava, a plant native to the Pacific islands, due to risk of liver dysfunction

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Interestingly, based on study evidence, sex differences also critically modulate oxidative stress responses and neurodegeneration susceptibility through distinct molecular mechanisms: Females exhibit superior antioxidant capacity via estrogenmediated Nrf2 activation, enhancing GSH synthesis and ROS clearance, while males demonstrate heightened vulnerability to oxidative DNA/lipid damage (e.g., elevated 8oxoG) due to androgendriven mitochondrial ROS overproduction [155]