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Briefly, 500 ng of genomic DNA per sample was bisulfite-converted (Zymo EZ DNA Methylation kit) and hybridized to the EPIC array, with arrays scanned on an iScan instrument to produce raw intensity data

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Some protocols recommend taking it on an empty stomach, first thing in the morning, to maximize absorption and align with the natural fasting state when lipolysis is already elevated

Notably, patients with reduced ejection fraction had higher absolute event rates, meaning the medication prevented more events in this higher-risk group

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