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Haematologica 97 (12), 18261835

Tryptophan, through its role in serotonin and kynurenine metabolism, also modulates the immune response by balancing pro-inflammatory and anti-inflammatory signals [55]

HER-2/neu encodes a receptor tyrosine kinase involved in mitogenic signaling via the MAPK and PI3K/AKT pathways and is implicated in the pathogenesis of multiple epithelial malignancies, including breast carcinoma

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Among them are modulation of inflammation, promotion of angiogenesis, enhancement of matrix remodeling and activation of repair-linked transcription programs