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The researchers concluded that defense mechanisms against reactive oxygen species are impaired in RA. To me, this sounds like a strong reason for anyone with RA to add active glutathione to their daily regimen
Indeed, the components of this system are involved in the bi-directional transport of acyl moieties from cytosol to mitochondria and vice versa, thus playing a fundamental role in tuning the switch between the glucose and fatty acid metabolism
The gradual escalation reduces side effects but creates a lag where patients pay full price for weeks before reaching therapeutic doses, which explains why some people quit before experiencing meaningful changes
Low GSH levels could also increase viral replication, pro-inflammatory cytokine release, endothelial damage, and immune-thrombosis, which is a hyper-coagulative clinical condition that could exacerbate morbidity and mortality in COVID-19 and PASC 598
