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Silica nanoparticles coated with polydopamine exhibit pH-sensitive mucus penetration, with diffusion rates approximately three times higher at pH 5.6 close to their isoelectric point than at more acidic (pH 3) or neutral (pH 7) conditions 184,185

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Pure R-ALA degrades at room temperature, is sensitive to heat and light, and can polymerize clumping into larger, inactive molecules at temperatures above 115120F (4649C).42 These issues make it difficult to manufacture and store

Vinchi et al