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The factors favoring escalation to 12mg include: weight loss plateau before reaching goal, BMI above 40 with significant weight to lose, and good tolerability with minimal side effects during escalation

The calculated caloric target was kept for the remainder of the trial except if a patient achieved a BMI of 22.5 kg/m 2 or lower, in which case the recommended energy intake was recalculated with no caloric deficit for the remainder of the trial