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All authors critically reviewed the manuscript and approved the final version

In addition to reducing alcohol and sugar intake and stopping smoking

18 Unlike some other copper containing compounds like copper chloride or copper acetate, GHK-Cu has not been found to be cytotoxic or to cause irritation topically, making it an ideal option for delivery of copper into the skin

Globally, the WHO and national health organizations could do the same

These enzymes can be used to metabolize ECM structural components (Wang et al., 2023) and reduce biofilm differentials by converting sessile cells into planktonic cells that are more susceptible to antimicrobial therapy