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Although preclinical studies in colon cancer models show that IDO1 inhibition can enhance T cell infiltration when combined with antiCTLA-4 therapy (125, 126), clinical trials of IDO1 monotherapy have demonstrated limited efficacy (127), reflecting tumor-specific metabolic adaptations and compensatory mechanisms

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155 The dysregulated proliferation of cancer cells leads to nutrient and oxygen deprivation, underlying the need for the formation of new blood vessels

There is a beneficial association between ALS and the intake of carotenes (Okamoto et al., 2009

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