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Clearance occurs primarily via enzymatic degradation by serum and tissue peptidases

People with a known allergy to cobalamin or cobalt should avoid them, and those with Leber's hereditary optic neuropathy should not receive B12

These findings extend our existing understanding of how fronto-striatal loops control the balance between goal-directed behaviour and habits, and how this balance may be related to the generation of compulsive responding

It is therefore part of a group of rare metabolic diseases that we will not discuss in this study

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