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This lipid peroxidation impairs sperm membrane function and Ca 2 signaling, compromising CatSper-dependent hyperactivated motility [359]

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The overwhelming dominance of ROS generated by enzymes like NADPH oxidases and xanthine oxidase over antioxidants like superoxide dismutase causes cell injury and tissue damage through direct injury, lipid peroxidation and protein oxidation leading to protease release and antioxidant and antiprotease enzyme inactivation as well as alteration of transcription factors activator protein-1 and NFB

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But as the springs get old or rusty, the trampoline starts to sag in the middle