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To infer whether the observed changes in transcriptional gene programmes indicative of reduced synaptic plasticity by GIPR antagonism and GLP-1R agonism in the DVC translate to altered signalling in the hypothalamus, we performed a cellcell communication analysis using the LIANA+ 49 implementation of the CellPhoneDB 50 algorithm, and the receptorligand database from NeuronChat 51 (Fig

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CNS Penetration of GLP-1RAs: Implications for Addiction As previously reviewed, numerous preclinical studies have demonstrated that GLP-1RAs can modulate drug-related behaviors across a variety of addiction models, including those involving alcohol, nicotine, psychostimulants, and opioids

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