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As a transcription factor, NRF2 translocates to the nucleus and activates genes containing antioxidant response elements (AREs), including heme oxygenase-1 (HO-1)and NRF2 itself [115]

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Mechanistically, the increase in CHAC1 expression in cancer cells can be linked to the induction of ferroptosis through the ATF4 mediated UPR branch (Wang et al., 2021)

Aerobic capacity, muscle mass, and strength all progressively decline with age

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