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The activation of mast cells caused the destruction of neighboring chondrocytes and the breakdown of cartilage.[ref] Related article: Osteoarthritis genes The figure below is from a study on mast cells in osteoarthritis (OA), showing both increased numbers of mast cells and an increase in tryptase

American Journal of Nephrology

However, this occurs primarily within muscle cells and often contributes to improved muscle fullness

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This narrative review highlights the main pharmacological strategies currently approved for the treatment of MASLD