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Managing side effects Most early side effects can be reduced or prevented with simple measures: Stay well hydrated throughout the day, especially during the first weeks at a new dose Eat smaller meals and stop eating before you feel completely full Limit greasy, fried, or very rich foods, which commonly trigger nausea Take a daily fiber supplement if constipation develops Use over-the-counter antacids if heartburn becomes uncomfortable Do not rush dose escalation

People with Digestive Issues: Conditions like Crohns disease, celiac disease, or irritable bowel syndrome can interfere with B12 absorption, making injections a more effective method of getting the nutrient

PMCID: PMC10785460

oral) to match your unique neurobiology

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