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These data extend prior work on SLC25A39 by showing that, in immune cells, SLC25A40 is present at baseline and is inducible by inflammatory stimulation, suggesting a regulatory mode distinct from the post-translational stability mechanism described for SLC25A39, highlighting different modes of control for the two transporters
In genetically susceptible individuals, these peptides are deamidated by tissue transglutaminase, presented mainly by HLA-DQ2 or HLA-DQ8, and drive both innate and adaptive immune activation
Three-protein signature is associated with baseline and persistently elevated or recurrent depressive symptoms in individuals with recent-onset diabetes
