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It is also indicated for certain patients with nondialysisdependent chronic kidney disease (NDD-CKD) and other approved/compendia-supported indications

Avoid Over-Dilution: Adding too much water (e.g., 10 mL to a 2 mg vial) results in a dilute solution, requiring larger injection volumes that may be impractical or uncomfortable

Powder Form: Store at -20C or lower in sealed containers with desiccants and under inert gas if possible

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div-1 mutants exhibit loss of asymmetry during early embryonic cleavages and result in the lacking of the endodermal and mesodermal cell fates (Encalada et al., 2000)