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Since patients are generally more willing to accept that trade-off following massive weight loss versus, say, a 20-pound change, surgeons are engineering new lift techniques for people who have lost smaller amounts of weight rapidly on GLP-1s

Lee et al., 2012

The first advantage of course is the improvement of blood sugar levels which on average results in a reduction of about one percentage point of glycated hemoglobin

thus, p53 may activate apoptotic protein and induce cellular death