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21, 2004, GSK: Knowingly promoted the sale and use of Zofran for a variety of conditions other than those for which its use was approved as safe and effective by the FDA (including hyperemesis and pregnancy-related nausea) Made and/or disseminated unsubstantiated and/or false representations or statements about the safety and efficacy of Zofran concerning its use for conditions, including hyperemesis and pregnancy-related nausea Offered and paid illegal kickbacks to health care professionals to encourage them to promote and prescribe Zofran, in violation of federal anti-kickback laws The DOJ described the settlement as the largest health care fraud settlement in U.S

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A day or two after I take my injection, I have no bowel movements at all

Most often, decreasing the dose or pausing therapy will improve minor-to-moderate gastrointestinal symptoms

This analysis highlights the ability to rapidly assess early real-world uptake of newly approved therapies within weeks of FDA authorization, enabling timely characterization of initial prescribing patterns as they emerge in clinical practice