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The dependence of BCL-2 activity has been demonstrated in both chemosensitive and chemoresistant myeloblasts but not in normal hematopoietic stem cells (HSCs) (Vo et al., 2012)

The findings from this analysis can have important clinical implications, considering that the daily duration of off-time for patients with Parkinsons disease can negatively impact their quality of life and that even a small change in the UPDRS motor scores can be clinically relevant [12, 23]

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