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During lead optimization, less-sensitive cell assays are valuable for distinguishing the contributions of affinity and efficacy in the cellular response to an agonist ( 29 )

In terms of energy expenditure, ALDH7A1 served as a pivotal node in HS-reconfigured metabolism, catalyzing the reduction of NADP to NADPH, which was then recycled by the antioxidant machinery [70]

Similarly, Singhal et al

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In recent years, mass spectrometry-based quantification methodsboth label-based and label-freehave become essential tools in proteomics