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Aged mice were divided into control and treatment groups, with the latter receiving intraperitoneal injections of FOXO4-DRI at doses of 0.5 mg/mL and 5 mg/kg every other day for 30 days, while controls received PBS

While the compound's primary mechanism involves reducing food intake through enhanced satiety, evidence suggests it also modestly increases resting energy expenditure through stimulation of noradrenergic pathways