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Fungal invasion typically initiates in the hyponychium, an area of low adhesion of the nail plate, and progresses along the longitudinal ridges of the nail bed, resulting in a linear appearance of the fungal infection.5 In onychoscopy, the most frequent finding is an irregular border pattern with spicules at the proximal margin of the onycholytic area

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Interestingly, cotreatment of MOTS-c and exendin-4 had an enhanced effect than MOTS-c alone in lowering the expression levels of senescence related genes ( Cd38 , Cdkn1a , Cdkn2a , Il1b , Il6 and Cxcl10 ) in NOD pancreatic -cells (Fig