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This age-related NAD+ depletion impairs mitochondrial energy production, reduces SIRT1 activity, compromises DNA repair mechanisms, and accelerates cellular senescence
Without controlled human exposure data, there is no validated human dose, treatment duration, monitoring programme, contraindication list or evidence-based interaction profile
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Sangle P, Sandhu O, Aftab Z, Anthony AT, Khan S. Vitamin B12 Supplementation: Preventing Onset and Improving Prognosis of Depre**ion. Cureus. 2020;12(10):e11169. Published 2020 Oct 26. doi:10.7759/cureus.11169
doi:10.1038/s41598-019-54932-2 Fan H, Zhou J, Yuan Z
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