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MRI can reveal changes in the ligaments microstructure, such as fiber alignment and density, which are indicative of stress and damage

For instance, antibodies targeting the ER stress-related protein GRP78 have been detected in the blood of SLE patients, with increased GRP78 and XBP1 expression observed in antibody-secreting plasma cells

In research settings, glutathione is commonly utilized in biochemical and in-vitro model systems to examine oxidative stress regulation, cellular defense mechanisms, mitochondrial function, and redox-sensitive signaling pathways

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J Clin Endocrinol Metab 109(8):2019-2028