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Sigma-1 receptor chaperones rescue nucleocytoplasmic transport deficit seen in cellular and Drosophila ALS/FTD models

The most important FAs in the brain and nerve system are omega-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)

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Fatty acid transport protein 4 (FATP4) further promotes intracellular retention of ALA through acyl-CoA formation, while members of the fatty acid-binding protein (FABP) family (I-FABP, L-FABP, FABPpm) chaperone -3 PUFAs toward the endoplasmic reticulum for re-esterification (5860)