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While direct comparisons between ablation and surgical excision are limited, numerous observational studies indicate that ablation provides acceptable rates of local control and long-term survival, along with superior cosmetic outcomes

While its exact cause remains unclear, IBS is increasingly understood as a multifactorial condition involving dysbiosis, gut-brain axis (GBA) dysfunction, visceral hypersensitivity, immune activation, and impaired gut motility and barrier integrity

In those, loss of NRF2 resulted in a more rapid onset and more severe clinical course of the EAE model, which was accompanied by increased glial activation, exacerbated spinal cord damage, and axonal degeneration as well as increased levels of proinflammatory cytokines (Rehman et al., 2019)

Chemosensory properties of the trigeminal system

Dihydroxyacetone induces G2/M arrest and apoptotic cell death in A375P melanoma cells