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They found a high rate of deficiency based on typical reference ranges and determined that it doesnt require 20 to 30 years of being vegetarian to develop a deficiency, a popular belief among vegetarians (Pawlak, 2013)

It was previously available through compounding pharmacies as a bulk drug substance, but the FDA reclassified it as a Category 2 substance, which effectively restricts compounding pharmacies from producing it

Cancer Prevention and Longevity Research in animal models suggests DSIP reduces tumor incidence and chromosomal defects ( 10, 12 )

Estrogen supports joint health by regulating collagen production, and its reduction can lead to increased inflammation, fibrosis, and musculoskeletal symptoms