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In the liver, a major site of GSH metabolism, this consists of: a) extensive catabolism of GSH within biliary spaces (Ballatori et al., 1986b, 1988, 1989), as well as within sinusoidal compartments of some species (Hinchman and Ballatori, 1990, 1994), b) direct hepatic reabsorption of some of the breakdown products (Ballatori et al., 1986a, 1988

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Many researchers believe that localized loss of pigment may be driven by an accumulation of hydrogen peroxide in the skin

5C) and closely match the common RGG/RG methylation motif of PRMT1

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