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And tell us the backstory

Chemotherapeutic agents, ionizing radiation, metabolites, and replication stresses cause continual DNA damage, which if repaired incorrectly may lead to somatic mutations and thus cell transformation or, if accumulated, can result in constant activation of the DNA damage response (DDR) and cause senescence

BioFactors 40(1):2740 Fernndez-Snchez A, Madrigal-Santilln E, Bautista M, Jaime Esquivel-Soto J, Morales-Gonzlez A, Esquivel-Chirino C, Durante-Montiel I, Snchez-Rivera G, Valadez-Vega C, Morales-Gonzlez JA (2011) Inflammation, oxidative stress, and obesity

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This means cleaner data, clearer interpretation, and fewer wasted experimental cycles