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The mechanisms behind addictive disorders have been extensively reviewed by several authors and comprise druginduced dysregulations of numerous neurocircuits and neurochemicals, such as dopamine, opioid peptides, corticotropinreleasing factor (CRF), dynorphin, glutamate and GABA, and also vulnerability factors such as genetics, initial drug exposure and social environment (Badiani et al., 2011

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However, for most people, this side effect may last for approximately 3 days and typically for no longer than 4 weeks

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