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The receptor exists in two splice variants: the active GHS-R1a, which binds acylated ghrelin, and the truncated GHS-R1b, which is pharmacologically inactive but can modulate the activity of 1a through heterodimerisation

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In mammals, whole body deletion of the coding gene ( mIndy , Slc13a5 ) increased energy expenditure and protected mice from diet-induced obesity and insulin resistance