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It is the primary site of insulin-mediated glucose disposal, meaning that losing it worsens the very insulin resistance that GLP-1 therapy is designed to improve

Food and Drug Administration for diabetic peripheral neuropathy: duloxetine (Cymbalta), pregabalin (Lyrica), tapentadol (available as brand Nucynta extended-release), and capsaicin patch (Qutenza)

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The core question for any blockbuster drug approaching loss of exclusivity is whether the brand can maintain a meaningful revenue stream in a world where patients and employers know what the generic acquisition cost actually is