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Traditionally, in vitro studies of intestinal biology have relied on immortalized cell lines, which, while informative, often fall short in recapitulating the intricate cellular interactions and physiological processes observed in the human intestine (169, 170)

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Melatonin inhibits mTOR-dependent autophagy during liver ischemia/reperfusion

*A phase 1 study evaluated the pharmacokinetic profile, safety, tolerability, and immunogenicity of the doses of AJOVY tested in the phase 2 and 3 trials (225 mg and 675 mg) following single administration in healthy subjects

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