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Regarding the complication burden, 34.6% of patients had at least one microangiopathy and 49.2% had macroangiopathy

Another key epigenetic mechanism that controls gene transcription involves chromatin remodeling mediated by the SWI/SNF complex, which has been revealed to be related to SLC7A11 transcriptional regulation (Ogiwara et al., 2019)

Mechanistic plausibility is lower-quality evidence than a human clinical trial

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