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Statements Author contributions KS and LB conceptualized the work and wrote the first draft of the manuscript

To inactivate LS GLP-1R neurons, we injected AAV expressing double-floxed EGFP and TeNT (AAV-DIO-EGFP-2A-TeNT) into the bilateral LS of GLP-1R-ires-Cre mice to achieve specific expression of EGFP-2A-TeNT in LS GLP-1R neurons (Figure 3A and Supplemental Figure 6C)

Total netgraph of (A) liver biopsy-based outcomes, (a) NAS, (b) fibrosis stage, (c) NASH resolution

Mild nausea is the most common, especially during the first 12 weeks

Injectable medications are packaged in containers made from type 1 borosilicate glass or a pharmaceutical-grade polymer