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In clinical settings, giving DSIP intravenously has been shown to reduce pain in most patients with chronic pain, including those with migraines and psychogenic pain

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(2019) 73:35463 e3

Importantly, a recent cost-effectiveness analysis using a Markov decision model showed that total thyroidectomy may be both more effective and less costly over the long term than continued medical therapy in euthyroid HT patients with disabling symptoms (58)