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Homocysteine-lowering therapy with supplemental B vitamins (folic acid, vitamin B 6 , and vitamin B 12 ) may be particularly useful in lowering the risk of stroke but appears to have little utility in the prevention of other cardiovascular events

Although most participants experienced GI-related adverse events, the majority were mild to moderate in severity and transient in duration, with no SAEs or clinically meaningful changes observed in vital signs or laboratory values

B12 supports the health of the gastrointestinal tract, helping to maintain proper digestion and absorption processes

Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC, et al

That may sound technical, but the practical meaning is simple