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By blocking NNMT, 5-Amino-1MQ prevents nicotinamide methylation, allowing NAD+ levels to rise and methyl groups to remain available for histone methylation and other epigenetic processes

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Other exclusion criteria were chronic renal replacement therapy (RRT), treatment limitation other than do-not-resuscitate, medical history of vasculitis, moribund (defined as an expected survival duration 30 kg/m 2 ) and non-obesity (BMI 30 kg/m 2 )

[7] In practice, some protocols use 1 mg IM monthly for maintenance once levels are stabilized