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Nat Med (2019) 25:3588

And yes, this alone may be what causes your leaky gut and your subsequent Ulcerative colitis

Quintana-Belmares RO, Krais AM, Esfahani BK, Rosas-Prez I, Mucs D, Lpez-Marure R, Bergman , Alfaro-Moreno E (2018) Phthalate esters on urban airborne particles: levels in PM10 and PM2.5 from Mexico City and theoretical assessment of lung exposure

It was just too weird

Therefore, from the maximum dose of 2.4mg, the patient stays on this dose for 4 weeks, then gets reduced to 1.7mg, then 1mg, then 0.5mg, then finally 0.25mg for 4 weeks, and then stops treatment